Abstract

Chemical tools that allow dynamic monitoring of enzyme activities through the formation of irreversible covalent bonds can be used for many diverse applications in basic biology as well as in drug discovery and clinical diagnostics. In this presentation, I will describe our efforts to design and build covalent binding small molecule probes using a range of techniques. Specifically, I will present recent advances in our development of fluorescent probes for applications in image guided cancer surgery as well as for the identification and imaging of several classes of serine hydrolases in pathogenic and commensal bacteria and cysteine proteases in viral pathogens. We believe many of these enzymes will represent valuable imaging and therapy targets that can be used to visualize and treat infections.

Biography

Dr. Bogyo is a Professor of Pathology and Microbiology and Immunology at Stanford University. He received his bachelor’s degree in Chemistry from Bates College in 1993 and a doctorate in Chemistry from Massachusetts Institute of Technology in 1997. Dr. Bogyo established an independent scientific career as a Faculty Fellow at the University of California, San Francisco in 1998. In 2001, Dr. Bogyo established the Chemical Proteomics Department at Celera Genomics focused on applying small molecule probes to the field of drug discovery. Dr. Bogyo then joined the Department of Pathology at Stanford University in July 2003 and was promoted to Associate Professor in 2009 and to full professor in 2013. Dr. Bogyo has published over 300 primary research publications and currently serves on the Editorial Board of several journals. Dr. Bogyo is also a member of Stanford’s Comprehensive Cancer Center, the Molecular Imaging Program at Stanford (MIPS) and is a consultant for several biotechnology and pharmaceutical companies in the Bay Area. He is the recipient of numerous awards including the Searle Scholar Award, The Terman Fellowship and the Burroughs Wellcome Investigators in Pathogenesis award. He is the co-founder of Akrotome Imaging, a company developing imaging contrast agents for detection of surgical margins.